REMS-certified Spravato® for treatment-resistant depression
A certified treatment center for esketamine, delivered in monitored, in-office sessions alongside your oral antidepressant.
When depression has not responded to standard antidepressants, Spravato® (esketamine) can be an option. We are a REMS-certified treatment center, which means we are authorized to administer esketamine under the program required by the FDA. Treatment happens in our office under clinical monitoring, and you continue taking an oral antidepressant alongside it.
Who it is for
- Adults with treatment-resistant depression, defined as inadequate response to two or more antidepressants
- Adults with major depressive disorder who have acute suicidal ideation or behavior, as part of a broader treatment plan
- Patients able to attend monitored, in-office sessions and arrange transportation home
REMS program disclosure
Spravato® is available only through a restricted program called the Spravato REMS because of the risks of sedation, dissociation, and the potential for abuse and misuse. Patients must be enrolled and treated at a certified center like ours.
Do not drive after treatment
After each session you must not drive or operate machinery until the next day, after a full night of sleep. Arrange transportation home before your appointment. Plan for a ride for every session.
What this visit includes
REMS-certified administration
Esketamine given in-office under the FDA-required Risk Evaluation and Mitigation Strategy program.
Clinical monitoring
You are observed by our team throughout each session.
Combined treatment
Spravato® is used together with an oral antidepressant, not instead of one.
Coordinated care
We work with your prescriber and keep your broader treatment plan aligned.
Your visit, step by step
Each session includes the esketamine treatment followed by a two-hour monitored observation period in our office. You will need a ride home and should not drive for the rest of the day. Diagnosis codes for this program fall under ICD-10 F33.x.
Frequently asked
Am I eligible for Spravato?
Spravato is for adults with treatment-resistant depression (failure of at least two antidepressants) or MDD with acute suicidal ideation. An evaluation confirms eligibility and reviews your history.
How long is each visit?
Plan for the treatment plus a two-hour monitored observation period afterward. You will be in the office for the full monitoring window.
Do I stop my other antidepressant?
No. Spravato is used together with an oral antidepressant. We coordinate the full plan with your prescriber.
Why do I need a ride home?
Esketamine can cause sedation and dissociation, so you cannot drive after a session. You must arrange transportation and avoid driving until the following day.
Is this the same as a ketamine infusion?
No. Spravato (esketamine) is an FDA-approved nasal spray delivered under a REMS program. It is a distinct, regulated treatment.
Ready to be seen?
Send a request and our team will reach out to schedule. For anything urgent, call 256-824-9602.